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Description
PD-L1 Recombinant Rabbit mAb,PBS Only (SDT-119-16)Product Specification Host Rabbit Antigen PD L1 Synonyms CD274, B7 H1 Immunogen Recombinant Protein Location Membrane Accession Q9NZQ7 Clone Number SDT 119 16 Antibody Type Rabbit mAb Application WB, IHC P, IF Reactivity Hu Purification Protein A Concentration 1 mg ml Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months from date of receipt, 4C as supplied Dilution application dilution species WB 1: 1000 IHC P 1: 100 1: 500 IF
Product Specification
| Host | Rabbit |
| Antigen | PD-L1 |
| Synonyms | CD274, B7-H1 |
| Immunogen | Recombinant Protein |
| Location | Membrane |
| Accession | Q9NZQ7 |
| Clone Number | SDT-119-16 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, IF |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt, 4°C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC-P | 1:100-1:500 | |
| IF | 1:100 |
Background
Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the adaptive arm of immune systems during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. The binding of PD-L1 to the inhibitory checkpoint molecule PD-1 transmits an inhibitory signal based on interaction with phosphatases (SHP-1 or SHP-2) via Immunoreceptor Tyrosine-Based Switch Motif (ITSM). This reduces the proliferation of antigen-specific T-cells in lymph nodes, while simultaneously reducing apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells) - further mediated by a lower regulation of the gene Bcl-2. Upregulation of PD-L1 on immune cells (especially myeloid cells) can also lead to formation of an immunosuppressive environment in a highly localized manner that also allow the cancer cells to proliferate.
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